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There has been no experience thus far with the use of METROGEL-VAGINAL in pregnant individuals. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly. No fetotoxicity or teratogenicity was observed when metronidazole was administered orally to pregnant mice at six instances the advised human dose (based upon mg/m2); on the other hand, in just one little analyze where by the drug was administered intraperitoneally, some intrauterine deaths were being observed. The connection of such conclusions into the drug is unidentified.
Metronidazole has shown evidence of carcinogenic activity in numerous experiments involving Serious oral administration in mice and rats. Well known amongst the results while in the mouse was the marketing of pulmonary tumorigenesis. This continues to be noticed in all 6 described studies in that species, including a person examine by which the animals have been dosed on an intermittent timetable (administration for the duration of every single fourth week only). At pretty superior dose concentrations (somewhere around 500 mg/kg/working day), there was a statistically important rise in the incidence of malignant liver tumors in males.
It is not recognized no matter if this medication will hurt an unborn toddler. Explain to your medical professional Should you be Expecting or prepare to become Expecting.
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In past scientific trials submitted for authorised labeling of METROGEL-VAGINAL the subsequent was also noted:
Do not get products that contains Liquor or propylene glycol although applying this medication and for a minimum of 24 several hours soon after stopping this medication. Talk to your pharmacist for more information.
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